HORDB

General Information

ID: hor005773
Uniprot ID: P06767
Protein name: Neuropeptide gamma
Gene name: Tac1
Organism: Rattus norvegicus (Rat)
Family: Tachykinin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0031835 substance P receptor binding; GO:0031837 substance K receptor binding
GO BP: GO:0002675 positive regulation of acute inflammatory response; GO:0006954 inflammatory response; GO:0007204 positive regulation of cytosolic calcium ion concentration; GO:0007217 tachykinin receptor signaling pathway; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007616 long-term memory; GO:0008217 regulation of blood pressure; GO:0008306 associative learning; GO:0009725 response to hormone; GO:0010459 negative regulation of heart rate; GO:0010634 positive regulation of epithelial cell migration; GO:0019233 sensory perception of pain; GO:0032224 positive regulation of synaptic transmission, cholinergic; GO:0032230 positive regulation of synaptic transmission, GABAergic; GO:0032496 response to lipopolysaccharide; GO:0045760 positive regulation of action potential; GO:0045778 positive regulation of ossification; GO:0048265 response to pain; GO:0050671 positive regulation of lymphocyte proliferation; GO:0051496 positive regulation of stress fiber assembly; GO:1902093 positive regulation of flagellated sperm motility; GO:1990090 cellular response to nerve growth factor stimulus; GO:2000854 positive regulation of corticosterone secretion
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030424 axon; GO:0043025 neuronal cell body; GO:0045202 synapse

Sequence Information

Sequence: GHGQISHKRHKTDSFVGLM
Length: 19(89-107)
Propeptide: MKILVAVAVFFLVSTQLFAEEIGANDDLNYWSDWSDSDQIKEAMPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRRK
Signal peptide: MKILVAVAVFFLVSTQLFA
Modification: T19 Methionine amide
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Mechanism: NA
Cross BBB: NA
Target: Tacr1, Tacr2
Target Unid: P14600, P16610
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: AF-P06767-F1(AlphaFold_DB_ID)

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005773_AF2.pdb

hor005773_ESM.pdb

Physical Information

Mass:	245668	Formula:	C92H147N31O26S
Absent amino acids:	ACENPWY	Common amino acids:	GH
pI:	10.79	Basic residues:	6
Polar residues:	6	Hydrophobic residues:	4
Hydrophobicity:	-80	Boman Index:	-4160
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	56.32
Instability Index:	6190.53	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

Literature

PubMed ID: 1695945
Title: Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma.
PubMed ID: 2433692
Title: Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.
PubMed ID: 2429656
Title: Se
PubMed ID: 1702066
Title:
PubMed ID: 8448217
Title:
PubMed ID: 7519424
Title:
PubMed ID: 2809597
Title: